Being socially isolated was associated with a 28% higher risk of incident dementia over 9 years, data from the National Health and Aging Trends Study showed. (Journal of the American Geriatrics Society)
Six minutes of high-intensity exercise boosted levels of brain-derived neurotrophic factor (BDNF), a protein involved in neuroplasticity, in 12 aerobically fit healthy young adults. (Journal of Physiology)
Manipulating gut microbiota in a mouse model of tauopathy led to a strong reduction in inflammation, tau pathology, and brain damage that was sex- and APOE-dependent. (Science)
After reports of fatal cases of acute liver failure in spinal muscular atrophy patients treated with onasemnogene abeparvovec (Zolgensma), the European Medicines Agency is preparing updated recommendations for the gene therapy.
Whistleblowers at the Journal of Clinical Investigation must disclose conflicts of interest after a group who flagged research about simufilam, Cassava Sciences’ investigational Alzheimer’s drug, allegedly profited from short-selling Cassava stock. (Nature)
Walking pace was inversely associated with new-onset dementia over a median follow-up of 12 years, U.K. Biobank data showed. (Alzheimer’s Research & Therapy)
Whether people were responsive during anesthesia was related to inherent differences in brain structure and function of frontoparietal networks, a MRI study suggested. (Human Brain Mapping)
Researchers identified 69 genes carrying somatic brain mutations in malformations of cortical development that cause intractable epilepsy. (Nature Genetics)
A new phase II trial will evaluate the investigational treatment tominersen in younger adults with a lower burden of Huntington’s disease, Ionis Pharmaceuticals announced.
Is migraine a risk factor for multiple sclerosis? (Neurology)
An essayist reflected on her family’s decision to donate her father’s brain to Alzheimer’s research. (Time)