Super-Agers and Tau; COVID Brain Findings; Sleep Habits of Sherlock Holmes

Cognitive super-agers — people over age 80 with superior memory capacity — appeared to resist tau tangles in the entorhinal cortex. (Cerebral Cortex)

APOE immunotherapy reduced cerebral amyloid angiopathy and amyloid plaques in mice without vascular complications. (Science Translational Medicine)

The International League Against Epilepsy and American Epilepsy Society issued an advisory to address concerns about the recent FDA cardiac risk warning regarding lamotrigine (Lamictal).

Six of 59 COVID-19 patients who underwent brain MRI had findings suggestive of COVID-related disseminated leukoencephalopathy. (American Journal of Roentgenology)

How COVID-19 affects the brain “might be the neurologic research question of our time.” (The Washington Post)

Noven Pharmaceuticals said it submitted a new drug application for its investigational amphetamine-based transdermal ADHD treatment.

The gammaCore vagus nerve stimulation device for migraine prevention and acute treatment has been approved for adolescents, device maker electroCore said.

The football position played may influence chronic traumatic encephalopathy (CTE) risk, a modeling study suggested. (Journal of Biomechanics)

Summary data from the NurOwn cell therapy trial in ALS were not convincing, but that does not preclude BrainStorm Cell Therapeutics from submitting a marketing application, the FDA said. (Endpoints News)

Brain organoids grown in the lab appeared to mature much like infant brains. (Nature Neuroscience)

Wake-up stroke was not linked to obstructive sleep apnea. (Sleep Medicine)

The world’s most famous fictional detective is called out for his sleep habits. (Lancet Neurology)