Novo Nordisk filed for FDA approval of its once-weekly GLP-1 receptor agonist Ozempic (semaglutide) at a higher dose of 2.0 mg. It’s currently available in 0.5-mg and 1-mg injectable dosing. (FiercePharma)
A small study found that people who stuck to a low-fat, plant-based diet tended to eat fewer calories, but also had higher insulin and glucose levels than those who ate a low-carb, animal-based diet. (Nature Medicine)
An analysis of children and adolescents from 49 different countries pointed to widespread overdiagnosis of thyroid cancer — similar to that seen in adults. “We suggest that the existing recommendation against screening for thyroid cancer in the asymptomatic adult population who are free from specific risk factors should be extended to explicitly recommend against screening for thyroid cancer in similar populations of children and adolescents,” the researchers wrote in Lancet Diabetes & Endocrinology.
Women with premature ovarian insufficiency likely have more severe menopause symptoms, like hot flashes, insomnia, and psychological problems. (Menopause)
If remission of Graves’ disease isn’t achieved after standard therapy of up to 18 months, long-term anti-thyroid drugs for 2 or more years may be preferred over radioiodine or surgical treatment. (Clinical Endocrinology)
A survey of 182 transgender women found that about 90% felt that a uterus transplant would improve their quality of life, while 99% said it would lead to greater happiness. (JAMA Network Open)
In related news, President Joe Biden selected Rachel Levine, MD, to serve as assistant secretary for health at HHS, which would make her the first openly transgender federal official to be confirmed by the Senate. (CNN)
Idiopathic intracranial hypertension — a brain pressure condition — is currently on the rise, linked to similarly rising obesity rates. (Neurology)