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Body Weight and Heart Disease; New Osphena Indication; Tofu and Appetite

Although 88% of American realize there’s a link between body weight and heart disease, only 43% said they’ve changed their diet to lose weight. Even more alarming, 40% overweight or obese individuals in this Cleveland Clinic-run survey said they’re not careful about their diet. (ScienceDaily)

In related news, counties tended to have lower rates of obesity when their residents used public transportation more often. “It will be interesting to see how Uber and Lyft as well as bike-share programs will influence this type of analysis in the future,” said coauthor Sheldon Jacobson, PhD, of the University of Illinois at Urbana, in a statement. (Transportation Research Part A: Policy and Practice)

The FDA approved an expanded indication for ospemifene (Osphena) to include moderate to severe vaginal dryness, the maker Duchesnay announced.

Compared with a meal consisting of processed meats and cheeses, a vegan meal with tofu received higher marks for satiety among healthy, obese, and diabetic men, while increasing levels of amylin. But the study didn’t compare a vegan meal to a non-vegan meal with unprocessed foods. (Nutrients)

A collaboration of researchers from Harvard, Mount Sinai, Mayo Clinic, and the Sansum Diabetes Research Institute received a grant to fund the first study of an artificial pancreas in pregnant women with type 1 diabetes. “Achieving and maintaining the very narrow range blood glucose levels required for the best fetal outcomes for pregnant women with type 1 diabetes is extremely challenging, even with optimal clinical care,” said Carol Levy, MD, of the Mount Sinai Diabetes Center.

Certain immune cells in the gut — intraepithelial T lymphocytes — may affect how diet causes obesity, hypercholesterolemia, hypertension, diabetes, and atherosclerosis, a mouse study suggested. (Nature)

After a positive meeting with the FDA, Entera Bio plans to initiate a dose-ranging study of its oral parathyroid hormone treatment for osteoporosis that will guide design for a phase III trial next year.

Looking at fast food and restaurant meals from India, Finland, Ghana, Brazil, the U.S., and China, the latter’s average calorie count ranked highest; the U.S. was second. (The BMJ)


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