Affective instability is the cornerstone symptom of borderline personality disorder (BPD), suggesting that inquiring about this single feature is a clinically useful screen for BPD, according to a new study. (Journal of Clinical Psychiatry)
A Mendelian randomization study found physical activity can be protective against major depression. “Knowing whether an associated factor actually causes an outcome is important, because we want to invest in preventive strategies that really work,” said lead author Karmel Choi, PhD, of Massachusetts General Hospital in Boston, in a statement. (JAMA Psychiatry)
On Feb. 28, 2019, the FDA will require that all prescribers and dispensers of clozapine (Clozaril) be certified with a clozapine risk evaluation and mitigation strategy (REMS) program.
When it comes to treatment-resistant depression strategies, what’s the most cost-effective alternate treatment? (Journal of Clinical Psychiatry)
Pairing a mood induction task and a wearable motion sensor, plus a machine warning algorithm, helped identify anxiety and depression in young kids. “If anxiety symptoms do not get detected early in life, they might develop into a full-blown anxiety and mood disorder,” said study author Maria Muzik, MD, of University of Michigan in Ann Arbor, in a press release. (PLOS One)
A simple blood test may predict familial Alzheimer’s disease up to 16 years before symptom onset. (Nature Medicine/MedPage Today)
In other news, researchers suggested a link between gum disease and Alzheimer’s disease in a mouse model. (Science Advances)
A phase II study assessing the investigational moderate-to-severe trichotillomania treatment is now underway, the developer Promentis Pharmaceuticals announced.