Researchers at Mount Sinai identified 14 gene variants associated with polycystic ovary syndrome (PCOS) in a large-scale whole-genome association study. “One of our most important findings is simply that all the fighting that goes on in the field over which diagnostic criteria to use is unnecessary,” said senior study author Andrea Dunaif, MD, of the Icahn School of Medicine at Mount Sinai, in a statement. “We can be pretty broad in our diagnosis with the criteria we have and be assured we are going to find the same genetic forms of PCOS.” (PLOS Genetics)
Off-label use of testosterone among men with coronary artery disease and age-related hypogonadism has remained relatively high even after the FDA’s 2015 warning about possible cardiovascular risk. (JAMA Internal Medicine)
End-stage kidney disease is increasing among people under age 50 with type 2 diabetes, found Australian researchers. “This is a really troubling finding but hopefully by improving medical care, by aggressively managing blood pressure and other cardiovascular risk factors in addition to blood sugar control, we can start to turn this around,” Jonathan Shaw, MD, of the Baker Heart and Diabetes Institute in Melbourne, said in a statement. (American Journal of Kidney Diseases)
Athenex announced the launch of their generic levothyroxine sodium for injection, available in 100, 200, and 500 mcg/vial doses for hypothyroidism.
People with obesity may require a much higher amount of radiation during x-rays, thus upping their risk for cancer. “We already started working on this issue in an attempt to produce prediction models that can aid radiographers to choose the best technical factors based on the patient’s size,” said lead author Saeed Al-Qahtani, a PhD candidate at the University of Exeter in England, in a statement. (Journal of Radiological Protection)
Unsurprisingly, more research suggested that being overweight and obesity in childhood and adolescence among boys was a strong indicator of later-life type 2 diabetes risk. (Journal of Clinical Endocrinology & Metabolism)
A mother was charged with involuntary manslaughter and endangering the life or health of a child after she failed to provide her 14-year old daughter proper medical treatment. The child, who had diabetes, died from diabetic ketoacidosis. (NBC News)
A researcher at Texas Biomedical Research Institute in San Antonio was awarded a $3 million grant to study obesity in Hispanic children. (KERA News)